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Relative contraindications requiring careful risk-benefit assessment include: cardiovascular disease (due to TB-500 angiogenic effects), Wilson's disease or copper metabolism disorders (GHK-Cu component), immunocompromised states (KPV anti-inflammatory effects), and renal impairment with creatinine clearance 65 years) show 25% higher incidence of side effects, likely due to decreased renal clearance and altered drug distribution

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Role of cytokines in endometriosis